PubMed · 7941528
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C R Koons. 1994. Breast implants and autoimmunity.. https://pubmed.ncbi.nlm.nih.gov/7941528/
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Neonatal lupus erythematosus is a disease primarily characterized by cardiac and/or cutaneous involvement. Liver and haematological involvement occur in a few cases and these are normally considered to be mild and transient complications. The disease is suspected to be caused by transplacental passage of maternal autoantibodies, primarily anti-Ro/SSA and anti-La/SSB, from mothers with systemic lupus erythematosus. Here we report a child with neonatal lupus erythematosus who died from severe liver and haematological disease when 2 d old. The baby had no cardiac or cutaneous involvement. The mother has had two subsequent pregnancies. In the first she had a boy without certain signs of neonatal lupus erythematosus. In the next pregnancy the child developed congenital complete heart block and cutaneous lesions.
A number of tests are available for diagnosis and follow-up evaluation of systemic rheumatic diseases. How accurate are they and when should they be used? Dr Ward discusses the specificity, sensitivity, and predictive values of various tests and explains which are most helpful for specific situations.