Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function.

A Hall; J R Knowles

doi:10.1038/264803a0

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Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function.

A Hall·J R Knowles

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Amidohydrolases Catalysis Cephalosporinase Drug Resistance, Microbial Escherichia coli Kinetics Mutation Penicillinase Plasmids Selection, Genetic Structure-Activity Relationship Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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A Hall, J R Knowles. Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function.. https://doi.org/10.1038/264803a0

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