PubMed · 79859
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R G Cotton. 1978-08-26. Additional rescue from methotrexate toxicity?. https://doi.org/10.1016/s0140-6736(78)91501-5
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The authors assessed in 18 patients with goitre the urinary excretion of neopterin and the blood level of thyroid hormones. They revealed a significant correlation between urinary neopterin excretion and the thyroxine (T4) and triiodothyronine (T3) blood level. This correlation did not apply in female patients treated with large doses of Carbimazol: these patients had a high neopterin excretion, while the thyroid hormone levels were only slightly elevated. This suggests again that Carbimazol has in addition to an antithyroid effect also an immunomodulating action.
Cell-free extracts from human full thickness skin (i.e., epidermis and dermis), suction blister roofs (i.e., epidermis) and from human keratinocytes express biopterin-dependent tyrosine hydroxylase a well as phenylethanolamine-N-methyl transferase, both representing key enzymes for the biosynthesis of epinephrine. These enzyme activities could not be detected in cell extracts from human melanocytes and human fibroblasts. Since keratinocytes in the human epidermis, and in cell cultures, express a high density of beta-2-adrenoceptors, and this signal transduction system regulates intracellular calcium homeostasis, it can be concluded that epinephrine production in the epidermis activates calcium transport via the beta-2-adrenoceptor system. Our results show for the first time that the human epidermis has the capacity to independently produce epinephrine.
GTP cyclohydrolase I of Escherichia coli has been purified from a recombinant bacterial strain. The enzyme was crystallized from 0.6 M-sodium citrate and from 0.8 M-sodium/potassium phosphate, respectively. Crystals grown in citrate showed X-ray diffraction extending to a resolution better than 3 A. The space group was P2(1) with cell dimensions a = 204.8 A, b = 210.1 A, c = 72.2 A, alpha = gamma = 90 degrees and beta = 95.8 degrees.