PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 799306

Clinical problems with HLA sensitization.

H F Polesky
View original source ↗Export metadata ↓

Abstract

There is little question that Frozen-Thawed-Deglycerolized Red Cells (Human) has the least amount of HLA antigen found in any red cell component. Units prepared by any of the several availables methods are indicated for patients with repetitive nonhemolytic febrile reactions, probably should be used in patients waiting for reanl allografts and in immunodeficient patients in whom there is a risk of GVH disease. Still unresolved are questions on the minimal dose of HLA needed to sensitize a recipient, the role of the debris and viable cells and whether transfusion with a small dose of HLA antigen has a beneficial effect on the survival of renal allografts.

Explore related subjects

Blood BanksBlood TransfusionChromium RadioisotopesErythrocytesFemaleFreezingHLA AntigensHemagglutinationHistocompatibility AntigensHumansImmunizationImmunologic Deficiency SyndromesIsotope LabelingKidney TransplantationMaleMethodsRenal DialysisTransplantation, HomologousJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H F Polesky. 1976. Clinical problems with HLA sensitization.. https://pubmed.ncbi.nlm.nih.gov/799306/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Regional transfusion centre preoperative autologous blood donation programme: the first two years.

OBJECTIVE: To assess the efficacy of a regional autologous blood donation programme. DESIGN: Clinical and laboratory data were collected and stored prospectively. Transfusion data were collected retrospectively from hospital blood bank records. SETTING: Northern Region Blood Transfusion Service and 14 hospitals within the Northern Regional Health Authority. SUBJECTS: 505 patients referred for autologous blood donation before elective surgery. MAIN OUTCOME MEASURES: Patient eligibility, adverse events from donation, autologous blood units provided, and autologous and allogeneic blood units transfused within 10 days of operation. RESULTS: Of 505 patients referred, 354 donated at least one unit. 78 of 151 referred patients who did not donate were excluded at the autologous clinic, mostly because of anaemia or ischaemic heart disease. In 73 cases the patient, general practitioner, or hospital consultant decided against donation. 363 autologous procedures were undertaken. In 213 (59%) cases all requested units were provided. The most common reasons for incomplete provision were late referral or anaemia. Adverse events accompanied 24 of 928 donations (2.6%). Transfusion data were obtained for 357 of the 363 procedures. 281 donors were transfused; autologous blood only was given to 225, autologous and allogeneic blood was given to 52, and allogeneic blood only was given to four. 648 of 902 (72%) units of autologous blood were transfused. Complete provision of requested autologous units was followed by allogeneic transfusion in 12 of 208 procedures (5.8%). Incomplete provision was followed by allogeneic transfusion in 44 of 149 procedures (30%). CONCLUSIONS: This study shows the feasibility of a regional autologous transfusion programme. Autologous donors only infrequently received allogeneic transfusion. Patients should be appropriately selected and referred early.

Blood Banks↗