PubMed · 8002059
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V Kalra. Iron and the developing brain.. https://doi.org/10.1007/bf02751882
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Iron deficiency is the most common nutritional deficiency in late infancy. In healthy term infants iron stores are depleted at the age of four to six months and the infant becomes increasingly dependent on exogenous sources of iron. Furthermore, the iron content and bioavailability in a traditional weaning diet are low. The consequences of iron deficiency in late infancy span from pallor to risk of impaired psychomotor development. Approaches to prevent iron deficiency and problems associated with these approaches are reviewed, and general guidelines for a weaning diet as well as guidelines with special emphasis on preventing iron deficiency are given. The present article identifies infants at high risk of developing iron deficiency including: immigrants, infants from a deprived background, infants to whom cows' milk is introduced early and/or given in large quantities, and infants from families with unusual eating habits. Finally, the commonly employed clinical practice for treating iron deficiency is mentioned.
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OBJECTIVE: To determine whether microcytosis is a typical finding in Shibas. DESIGN: Prospective study. ANIMALS: 18 Shibas. PROCEDURE: Blood and serum samples were obtained for automated hematologic analyses (18 dogs) and for determination of ferritin concentration, using ELISA (14 dogs). Blood samples from 30 clinically normal dogs of various other breeds was analyzed to establish a reference range for ferritin concentration. RESULTS: Erythrocyte mean corpuscular volume in Shibas ranged from 55.6 to 69.1 fl (mean+/-SD, 61.2+/-4.3 fl; median, 60.6 fl; reference range, 63 to 73 fl). Microcytosis was identified in 12 of 18 dogs. Males and females were affected equally. Mean corpuscular hemoglobin concentration was slightly low (range, 32.0 to 33.9%; reference range, 34 to 38%) in 6 dogs, 4 of which had microcytic RBC. Serum ferritin concentrations ranged from 61.2 to 277.0 ng/ml (mean+/-SD, 110.6+/-51.4 ng/ml; median, 106 ng/ml). Reference range for serum ferritin concentration was 50.7 to 440.0 ng/ml (mean+/-SD, 121.2+/-67.1 ng/ml; median, 111.5 ng/ml). Thrombocytopenia (range, 110,000 to 196,000 platelets; reference range, 200,000 to 450,000 platelets) was found in 7 dogs, 6 of which also had microcytic RBC. CLINICAL IMPLICATIONS: Microcytosis can be a typical finding in Shibas. Common origin of Shibas and Akitas, a breed predisposed to microcytosis, suggests a hereditary basis for this finding.