On the antigenic diversity threshold model for AIDS.

N I Stilianakis; D Schenzle; K Dietz

doi:10.1016/0025-5564(94)90072-8

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On the antigenic diversity threshold model for AIDS.

N I Stilianakis·D Schenzle·K Dietz

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Abstract

In this paper stochastic simulations of a model for AIDS pathogenesis developed by Nowak and coworkers are presented. The results reveal a strong dependency on initial conditions, and the model predicts a nonmonotonic hazard rate for the transition to AIDS. Doubts are raised concerning the significance of the "antigenic diversity threshold," since it only partially characterizes the model dynamics.

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Acquired Immunodeficiency Syndrome Antigenic Variation HIV Humans Mathematics Models, Biological Stochastic Processes Time Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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N I Stilianakis, D Schenzle, K Dietz. 1994. On the antigenic diversity threshold model for AIDS.. https://doi.org/10.1016/0025-5564(94)90072-8

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