A potential biomaterial composite for dermal and subcutaneous augmentation.

B L Eppley; D J Summerlin; A M Sadove

doi:10.1097/00000637-199405000-00004

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PubMed · 8060068

A potential biomaterial composite for dermal and subcutaneous augmentation.

B L Eppley·D J Summerlin·A M Sadove

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Abstract

Based on previous experimental connective tissue work in cutaneous wound healing, cell culture, and fat transplantation, the use of positively charged dextran beads for subcutaneous and dermal augmentation was evaluated. When combined with a biocompatible liquid medium, the material easily flowed through small-gauge needles. When injected beneath the facial skin in rats, a profound macrophage response was initially seen at 30 days accompanied by fibroblast proliferation and new collagen formation. By 1 year, a quiescent noninflammatory cellular response with extensive intermaterial collagen deposition was evident. No adverse reactions were seen in the contralateral facial sites, which were injected with only the liquid medium. These preliminary findings suggest good tissue compatibility of this composite biomaterial and provide further evidence of the significant regulatory role of the macrophage in the tissue response to implanted biomaterials.

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Animals Biocompatible Materials Connective Tissue DEAE-Dextran Dermatologic Surgical Procedures Female Foreign-Body Reaction Injections, Subcutaneous Materials Testing Prostheses and Implants Rats Rats, Sprague-Dawley Skin Surgery, Plastic Wound Healing Journal Article

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B L Eppley, D J Summerlin, A M Sadove. 1994. A potential biomaterial composite for dermal and subcutaneous augmentation.. https://doi.org/10.1097/00000637-199405000-00004

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