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PubMed · 8083863

Correlation between beta- and alpha-adrenergic receptor concentrations in human placenta.

G Falkay·K Melis·L Kovács
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Abstract

alpha 2- and beta-adrenergic receptors in human placental membranes have been investigated using the radioligands [3H]-RX 821002 and [3H]-dihydroalprenolol, respectively. The specific binding of the alpha 2-adrenoceptor antagonist RX 821002 confirms the presence of an alpha 2-adrenoceptor in the human placenta, which has been characterized previously with [3H]-rauwolscine. The major finding presented here is a correlation between the alpha 2- and beta-adrenergic receptor concentrations (r = 0.765) in the human placenta at term. It is suggested that the alpha 2/beta adrenoceptor balance may play an important role in regulation of the vascular bed of the placenta. Determination of the alpha 2/beta ratio may help towards an understanding of the contractility of the placental vascular muscles.

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DihydroalprenololDioxanesFemaleHumansIdazoxanPlacentaPregnancyReceptors, Adrenergic, alpha-2Receptors, Adrenergic, betaJournal ArticleResearch Support, Non-U.S. Gov't

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G Falkay, K Melis, L Kovács. 1994. Correlation between beta- and alpha-adrenergic receptor concentrations in human placenta.. https://doi.org/10.3109/10799899409066030

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