PubMed · 8086899
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
S Iliffe, S S Tai, M Gould, M Thorogood, M Hillsdon. Prescribing exercise in general practice.. https://doi.org/10.1136/bmj.309.6953.494
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Cardiac rehabilitation is an important management strategy in patients with coronary artery disease. Substantial data from both mortality and morbidity studies support the benefits. Recent studies of patients with coronary artery disease have shown that exercise confers greater benefit in those who are also on a fat-controlled diet than in those who are not. In addition, high-intensity exercise has been found to improve left ventricular function in men with coronary artery disease. Individual home exercise programs, both with and without telephone monitoring, are prescribed by physicians and health care professionals for an increasing number of patients. Aggressive modification of coronary risk factors is also incorporated in the overall cardiac rehabilitation program, and the concept of greater total kilocalorie expenditure per week is emphasized.
Our knowledge of the mechanisms leading to exercise intolerance is constantly expanding. Since the discovery of the glycolysis pathway block caused by phosphorylase deficiency as the cause of McArdle's disease, several other glycolysis blocks have been identified constituting a first group of exercise intolerance syndromes. A second group involves mitochondrial anomalies. More recently diverse exercise intolerance syndromes have been associated with insufficient regulation of calcium flow through the sarcoplasmic reticulum, particularly in sporadic cases of malignant hyperthermia with or without hyperthermia. A discrete form of dystrophinopathy is expressed by exercise-induced myalgia with myoglobinuria. Proximal myotonic myopathy also produces pain at exercise. The specificity of other syndromes such as AMP deaminase deficiency or myopathy with tubular aggregates remains debatable. Our understanding of these different syndromes, and their recognized or yet to be elucidated causes, is of practical significance for developing exploration protocols for patients with exercise intolerance with or without myoglobulinuria.