Kainate-binding proteins: phylogeny, structures and possible functions.

J M Henley

doi:10.1016/0165-6147(94)90146-5

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Kainate-binding proteins: phylogeny, structures and possible functions.

J M Henley

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Abstract

Recent advances have demonstrated that the family of [3H]kainate-binding proteins and kainate receptors comprise a number of related polypeptides. In all the cases so far investigated, the kainate-binding proteins from non-mammalian vertebrates have M(r) values in the range of 40-50 kDa whereas mammalian kainate receptors and kainate-binding proteins have M(r) values in the order of 100 kDa. There have not, as yet, been any reports of 40-50 kDa kainate-binding proteins in mammalian CNS and, despite the cloning of increasing numbers of cDNAs encoding new kainate-binding proteins, the relationships between these two general groups of polypeptides remain unclear. Nonetheless, there is now a wealth of phylogenetic, structural and molecular biological data available about these proteins. In this review, Jeremy Henley outlines the properties and structures of kainate-binding proteins and offers some possibilities as to the roles of these often hugely abundant proteins.

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Amino Acid Sequence Animals Carrier Proteins Central Nervous System Humans Kainic Acid Mammals Molecular Sequence Data Molecular Weight Kainic Acid Receptors Vertebrates Journal Article Research Support, Non-U.S. Gov't Review

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J M Henley. 1994. Kainate-binding proteins: phylogeny, structures and possible functions.. https://doi.org/10.1016/0165-6147(94)90146-5

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