PubMed · 8118598
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W W Bailey. 1994. Interrupted aortic arch.. https://pubmed.ncbi.nlm.nih.gov/8118598/
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STUDY DESIGN: The present study describes anatomic observations on great medullary artery and intercostal arteries pertinent to thoracolumbar spinal surgery. OBJECTIVES: This study reveals the vulnerable course of the great medullary artery and its relationship to the lateral or posterolateral approach to thoracic spine. SUMMARY OF BACKGROUND DATA: There are no previous anatomic data on the length of the great medullary artery, its intradural course, its relationship with the anterior spinal artery, and the distance between two adjacent intercostal arteries. METHODS: The location of the intercostal arteries was defined, and the distance between two adjacent arteries was measured at a point on the lateral surface of the vertebra midway between its anteroposterior diameter. The intradural length of the great medullary artery and the angle it formed with the anterior spinal artery at the point of anastomosis were also measured. RESULTS: The mean intradural length of the great medullary artery was 3.6 cm (range, 1.7-8.1 cm), and it passed over 1-3 disc spaces before joining the anterior spinal artery at a mean angle of 20.1 degrees (range, 12-28 degrees). The average distance between two adjacent intercostal arteries from T6 to L2 was 3.6 cm (range, 2.8-4.0 cm), which provides a safe window through which a herniated thoracic disc may be approached if surgery is indicated. CONCLUSIONS: The acute angle between the great medullary artery and anterior spinal artery indicates that these two arteries are in close proximity for considerable length and are liable to be compressed together with the intervening vascular collaterals by a space-occupying lesion, such as disc herniation or a fractured fragment. The longer the intradural course of the great medullary artery, the more vulnerable it is to compression by disc herniation or fracture. The intercostal and lumbar arteries are located at the midportion of the lateral aspect of the vertebral bodies rather than at the level of intervertebral discs. Discectomy or decompression of the anterior thoracic canal may be accomplished through a lateral or posterolateral extracavitary approach between two intercostal or lumbar arteries.
To approach the mechanism of the stimulating effect of linoleic acid hydroperoxide on the production of matrix metalloproteinases (MMPs) in human aortic intimal smooth muscle cells (ISMC), we investigated the effect of the hydroperoxide on the cytosolic level of Ca2+. Linoleic acid hydroperoxide provoked an increase in the cytosolic Ca2+ level, but it had no effect on the level of inositol phosphates (IPs) in these cells, in contrast with the effect of platelet-derived growth factor (PDGF), which elevated the level of both Ca2+ and IPs in these cells. A23187, a calcium ionophore, stimulated ISMC to produce matrix prometalloproteinase 1. These results indicate that linoleic acid hydroperoxide stimulates the production of MMPs in ISMC by elevation of the cytosolic Ca2+ level without the intervention of IPs. In addition, we found that the hydroperoxide has no effect on the binding of PDGF to its specific receptor on ISMC.
In this study, mechanical characteristics of descending thoracic aorta were evaluated after preservation at +4 degrees C in EuroCollins solution or after programmed cryopreservation with 15% dimethylsulfoxide and compared to control segments. Arterial allografts were procured from multiple organ harvesting over a period of 2 years. All the segments were allowed to incubate in EuroCollins enriched antibiotics solution for 18 to 24 hr after harvest and were then tested as a control group or preserved at +4 degrees C in EuroCollins solution for 4, 7, 21, and 31 days or cryopreserved for 2 or 4 months. Each aorta was cut into parallel blades either in the radial or in the circumferential direction and mounted over a traction-compression apparatus for mechanical testing. Stress-strain characteristics indicated that no discernible differences were found between cryopreserved aorta and the control group. For those preserved at +4 degrees C a greater high strain modulus was noted for graft preserved for 21 and 31 days; however, this difference was not statistically significant. The authors concluded that cryopreservation did not alter the mechanical characteristics of arterial allografts procured from multiple organ harvesting.