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Case report: silent thyroiditis developed during alpha-interferon therapy.

K Kamikubo·R Takami·T Suwa·Y Kawase·J Shiroko·M Kametani·N Tokimitsu·S Sakata
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Abstract

Alpha-interferon (IFN-alpha) was used for the treatment of chronic active hepatitis C in a 30-year-old woman who was euthyroid but had low titers of antithyroid antibodies before treatment. Two months after the initiation of IFN-alpha therapy she became thyrotoxic. She had nontender diffuse goiter. A laboratory examination revealed elevated levels of serum free thyroid hormones and a suppressed concentration of serum thyrotropin. Titers of antimicrosomal antibodies increased. The anti-thyrotropin receptor antibody was negative. A 99mTcO- scintigram of the thyroid showed reduced uptake. During the IFN therapy free thyroid-hormone levels started to decline. The IFN-alpha therapy was completed 1 month after the onset of thyrotoxicosis. Two months after the completion of the therapy the patient became euthyroid and 99mTcO- uptake was normalized. It is likely that preexisting chronic thyroiditis was exacerbated to cause silent thyroiditis during IFN-alpha therapy. None of the other 11 patients with chronic hepatitis C who had had no anti-thyroid antibodies and were treated with IFN-alpha showed anti-thyroid antibodies and thyroid dysfunction after the therapy. It is advisable to assess anti-thyroid antibodies and thyroid function in patients who are going to receive IFN-alpha treatment.

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AdultFemaleGoiterHepatitis CHumansInterferon Type IRadionuclide ImagingRecombinant ProteinsTechnetiumThyroid GlandThyroiditisThyroxineTime FactorsTriiodothyronineCase ReportsJournal Article

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K Kamikubo, R Takami, T Suwa, Y Kawase, J Shiroko, M Kametani, N Tokimitsu, S Sakata. 1993. Case report: silent thyroiditis developed during alpha-interferon therapy.. https://doi.org/10.1097/00000441-199309000-00009

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