mu-Chain gene expression in common variable immunodeficiency.

K Mushiake; F Motoyoshi; N Kondo; T Orii

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PubMed · 8136175

mu-Chain gene expression in common variable immunodeficiency.

K Mushiake·F Motoyoshi·N Kondo·T Orii

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Abstract

Three patients with common variable immunodeficiency (CVID) were analyzed for translation from mu mRNA by the cell-free translation method and for expression of mu mRNA by northern blotting. In cases 1 and 2, the mu chain was not detected in the products by cell-free translation nor was mu mRNA detected by northern blotting. In case 3, mu mRNA was detected at a low level. This suggests that the disorders occur between rearrangement of the Ig genes and transcription of the C mu gene in cases 1 and 2, and that the functions of rearrangement and transcription are qualitatively preserved to a certain degree in case 3. Thus, the pathogeneses of CVID are variable and more research on regulatory mechanisms of B cell development is necessary to understand each case of CVID.

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B-Lymphocytes Child Child, Preschool Common Variable Immunodeficiency Gene Expression Gene Rearrangement, B-Lymphocyte, Heavy Chain Humans Immunoglobulin Constant Regions Immunoglobulin mu-Chains Male Protein Biosynthesis RNA, Messenger T-Lymphocytes Transcription, Genetic Case Reports Journal Article

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K Mushiake, F Motoyoshi, N Kondo, T Orii. 1993. mu-Chain gene expression in common variable immunodeficiency.. https://pubmed.ncbi.nlm.nih.gov/8136175/

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