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PubMed · 8171323

A lymphotoxin-beta-specific receptor.

P D Crowe·T L VanArsdale·B N Walter·C F Ware·C Hession·B Ehrenfels·J L Browning·W S Din·R G Goodwin·C A Smith
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Abstract

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.

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Amino Acid SequenceBase SequenceBinding SitesCysteineHumansHybridomasLigandsLymphotoxin beta ReceptorLymphotoxin-alphaMolecular Sequence DataReceptors, Tumor Necrosis FactorRecombinant Fusion ProteinsT-LymphocytesTetradecanoylphorbol AcetateTumor Necrosis Factor-alphaCommentJournal ArticleResearch Support, Non-U.S. Gov't

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P D Crowe, T L VanArsdale, B N Walter, C F Ware, C Hession, B Ehrenfels, J L Browning, W S Din, R G Goodwin, C A Smith. 1994-04-29. A lymphotoxin-beta-specific receptor.. https://doi.org/10.1126/science.8171323

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