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PubMed · 8178526

[Genetic and immunologic studies after space flight].

H Tuschl·R Kovac·W Klein·E Ott·Y I Voronkov·M Kaidakow
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Abstract

The effect of spaceflight on lymphocytes of the peripheral blood was investigated in the Austrian cosmonaut flying the Austro-Soviet mission Austromir. Blood was sampled before and after flight, and the following parameters studied: quantities of lymphocytic subsets (T cells, helper cells, suppressor cells, B cells and natural killer cells); mitogenic stimulation of lymphocytes--DNA (= deoxyribonucleic acid) synthesis and expression of Interleukin-2-receptor; structural modification of DNA, unscheduled DNA synthesis and sister chromatid exchanges. Besides reducing the number of natural killer cells, spaceflight caused on impairment of lymphocyte activity and a slight modification of DNA structure. 4 weeks after flight, control values were reestablished, indicating efficient repair mechanisms.

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Chromosome AberrationsDNA DamageDNA RepairHumansImmune ToleranceImmunocompetenceLeukocyte CountLymphocyte ActivationRisk FactorsSister Chromatid ExchangeSpace FlightT-Lymphocyte SubsetsWeightlessnessEnglish AbstractJournal Article

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H Tuschl, R Kovac, W Klein, E Ott, Y I Voronkov, M Kaidakow. 1993. [Genetic and immunologic studies after space flight].. https://pubmed.ncbi.nlm.nih.gov/8178526/

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