Rhesus monkey platelet kinetics and storage.

L N Button; M S Jacobson; S V Kevy

doi:10.1046/j.1537-2995.1976.16476247050.x

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Rhesus monkey platelet kinetics and storage.

L N Button·M S Jacobson·S V Kevy

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Abstract

Rhesus monkey platelets that are separated, 51Cr labeled, and transfused provide yields, 1/2 time and survivals similar to those obtained in man. Rhesus platelets prepared and stored at room temperature for three days have 93 per cent of the yield of fresh platelets. When prepared and stored at 4C, the yield is only 54 per cent of fresh platelets. Rhesus repeatedly transfused with platelets from random unmatched donors always have a significant decrease in the platelet 1/2 time and survival. This was observed after the second homologous transfusion in one and after the third in others. The rhesus provides an excellent platelet model with thrombocyte responses mimicking those of man.

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Animals Blood Cell Count Blood Platelets Blood Preservation Blood Transfusion Cell Survival Haplorhini Histocompatibility Kinetics Macaca mulatta Models, Biological Temperature Time Factors Journal Article Research Support, U.S. Gov't, P.H.S.

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L N Button, M S Jacobson, S V Kevy. Rhesus monkey platelet kinetics and storage.. https://doi.org/10.1046/j.1537-2995.1976.16476247050.x

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