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PubMed · 8225504

Monitoring occupational exposure to carcinogens.

B Schoket
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Abstract

32P-Postlabelling has been used for biomonitoring occupational exposure to complex mixtures of polycyclic aromatic hydrocarbons in iron foundries, coke oven and aluminium plants and among roofers and surface-coating workers. Enhanced levels of aromatic DNA adducts have been detected in exposed populations in comparison to controls. Dose-related adduct formation has been found in iron foundry and coke-oven workers and roofers. The importance of longitudinal biomonitoring has been shown in two aluminium plants. Comparison between 32P-postlabelling and immunoassays revealed wide variations. DNA adduct levels obtained by the current methods should thus be regarded as relative values between individuals and control and exposure groups.

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CarcinogensDNADNA DamageEnvironmental MonitoringEvaluation Studies as TopicHumansOccupational ExposureOccupationsPhosphorus RadioisotopesSensitivity and SpecificitySingle-Strand Specific DNA and RNA EndonucleasesJournal ArticleReview

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B Schoket. 1993. Monitoring occupational exposure to carcinogens.. https://pubmed.ncbi.nlm.nih.gov/8225504/

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