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Adrenoceptor coupling mechanisms which regulate salivary secretion during aging.

A Miyamoto·T Araiso·T Koyama·H Ohshika
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Abstract

In parotid slices and membranes from Wistar rats 2, 12 and 24 months old, changes are noted in adrenoceptor-stimulated K+ fluxes, formation of [3H]inositol phosphates ([3H]IPs), cAMP production, and membrane environment. Norepinephrine-stimulated K+ efflux and formation of [3H]IPs in the slices proceed through an alpha 1-adrenergic mechanism and are reduced 20% and 40% during aging, respectively. In beta-adrenoceptor stimulation with isoproterenol, no age changes were observed in K+ influx and cAMP production. The cholesterol content in membranes was reduced with age; concomitantly, the membrane viscosity decreased with age. These results indicate that the alterations in the membrane environment may provide age-dependent modulation of alpha 1-adrenoceptor coupling mechanisms and their functions.

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AgingAnimalsCell MembraneCyclic AMPIn Vitro TechniquesInositol PhosphatesIsoproterenolNorepinephrineParotid GlandPhospholipidsPotassiumRatsRats, WistarReceptors, Adrenergic, alpha-1Receptors, Adrenergic, betaSalivaSalivary Proteins and PeptidesViscosityJournal ArticleResearch Support, Non-U.S. Gov't

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A Miyamoto, T Araiso, T Koyama, H Ohshika. 1993. Adrenoceptor coupling mechanisms which regulate salivary secretion during aging.. https://doi.org/10.1016/0024-3205(93)90026-y

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