[A decrease in the hydrodynamic resistance in the mesenteric arterioles of rats injected with the polyethylene oxide Polyox WSR-301].

I A Sokolova; A A Shakhnazarov; M I Timkina; M S Poliakova; A V Priezzhev; S G Proskurin; N B Savchenko; K F Bikkulova

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PubMed · 8312561

[A decrease in the hydrodynamic resistance in the mesenteric arterioles of rats injected with the polyethylene oxide Polyox WSR-301].

I A Sokolova·A A Shakhnazarov·M I Timkina·M S Poliakova·A V Priezzhev·S G Proskurin·N B Savchenko·K F Bikkulova

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Abstract

The infusion of polyethylene oxide in anesthetised rats in a total dose of 10(-7) g/ml caused a 10-16% reduction in blood pressure. This injection has been associated with 17% decreased pressure (servo-nulling method) and 54% increased blood velocity (laser Doppler fluxmetry) in mesenteric arterioles (d - about 24 mu), but no increase in their internal diameter was observed (image-split method). Vasodilatation (adenosine, 10(-5) M) did not change the hemodynamic response of the arterioles to polymer infusion. These results suggest that microdisturbances of blood flow which can be diminished by drug-reducing polymers are more important for the vascular resistance to blood than it has been previously.

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Animals Arterioles Biophysical Phenomena Biophysics Blood Flow Velocity Blood Pressure Male Mesenteric Arteries Polyethylene Glycols Rats Rats, Wistar Vascular Resistance Comparative Study Journal Article

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I A Sokolova, A A Shakhnazarov, M I Timkina, M S Poliakova, A V Priezzhev, S G Proskurin, N B Savchenko, K F Bikkulova. 1993. [A decrease in the hydrodynamic resistance in the mesenteric arterioles of rats injected with the polyethylene oxide Polyox WSR-301].. https://pubmed.ncbi.nlm.nih.gov/8312561/

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