PubMed HealthSearch

PubMed · 831930

A simple computer program for optimization of source loading in cervical intracavitary applicators.

Abstract

A computer program has been developed to aid in the brachytherapy of cancer of the cervix. Using a least-squares minimization algorithm, the program will optimize the source loading in intracavitary applicators so as to reproduce, as nearly as physical considerations allow, the dose distribution requested by the user. Applicator geometry and the relative positions of anatomical points of interest must be supplied to the program, as well as an inventory of available source strengths. Output from the computer includes the optimized source loading, time of application, and the resulting relative doses to the various user-selected points of interest.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

L M Rosenstein. 1977. A simple computer program for optimization of source loading in cervical intracavitary applicators.. https://doi.org/10.1259/0007-1285-50-590-119

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Molecular orbital study on the glutathione-dependent detoxication of ozonides.

The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations suggest that the reaction of glutathione with ozonides involves a nucleophilic attack at one of the carbon atoms of the ozonide ring, instead of at one of the peroxidic oxygen atoms of the ozonide ring. This implies a mechanism different from that of the glutathione S-transferase-mediated reaction with hydroperoxides, previously proposed for the glutathione-dependent detoxication of fatty acid ozonides.

Computers