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Reserpine and cerebral vasospasm.

C Watts
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Abstract

Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance as the vasospastic element in dog blood responsible for experimental vasospasm from topically applied whole blood. Other experimental data support these findings.

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AnimalsBasilar ArteryDisease Models, AnimalDogsIschemic Attack, TransientMethysergideReserpineJournal Article

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C Watts. Reserpine and cerebral vasospasm.. https://doi.org/10.1161/01.str.8.1.112

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