Diatrizoate in computed cranial tomography: a quantitative study.

I E Leppik; C J Thompson; R Ethier; A L Sherwin

doi:10.1097/00004424-197701000-00008

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Diatrizoate in computed cranial tomography: a quantitative study.

I E Leppik·C J Thompson·R Ethier·A L Sherwin

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Abstract

Plasma diatrizoate concentrations during computed cranial tomography were measured by UV spectrophotometry in 14 patients. A loading dose of 0.82 mg diatrizoate/kg followed by a stead infusion of 0.01 mg/kg was required to attain and maintain plasma concentrations of approximately 400 mg/100 ml. Lowering the beam energy resulted in a substantial increase in the EMI numbers of diatrizoate and significant improvement in the delineation of contrast containing lesions. A contrast index estimating the volume of pixel containing diatrizoate was calculated for five diagnosed lesions and this factor appears to be related to vascularity and extravasation.

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Adenocarcinoma Adult Brain Diseases Brain Neoplasms Contrast Media Diatrizoate Diatrizoate Meglumine Female Humans Intracranial Arteriovenous Malformations Intracranial Embolism and Thrombosis Male Meningioma Middle Aged Neoplasm Metastasis Radiography Journal Article

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I E Leppik, C J Thompson, R Ethier, A L Sherwin. Diatrizoate in computed cranial tomography: a quantitative study.. https://doi.org/10.1097/00004424-197701000-00008

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