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Hyperparathyroidism induced by hypothyroidism.

R P Walker·R Oslapas·K Ernst·P Hessel·R Nayyar·A M Lawrence·E Paloyan
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Abstract

The coexistence of hyperparathyroidism and thyroid tumors and/or chronic thyroiditis has raised the possibility of an etiologic relationship. The present study was designed to test the hypothesis that the chronic elevation of thyroid-stimulating hormone (TSH) is related to the development of hyperparathyroidism. Three groups of 24 rats each were treated for 12 weeks as follows: group 1 received propylthiouracil (PTU) in their deionized water; group 2 received PTU and thyroid hormone to suppress TSH and to serve as a control group for possible direct effects of PTU; and group 3 was not treated at all and served as another control group. At 12 weeks, 95% of group 1 rats (PTU only) showed hyperplasia of the parathyroids with a 30% mean increase in circulating parathormone.

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Administration, OralAnimalsCalciumDelayed-Action PreparationsDrug ImplantsFemaleHyperparathyroidismHyperplasiaHypothyroidismParathyroid GlandsParathyroid HormonePhosphorusPropylthiouracilRatsRats, Sprague-DawleyThyroid GlandThyrotropinThyroxineJournal ArticleResearch Support, Non-U.S. Gov't

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R P Walker, R Oslapas, K Ernst, P Hessel, R Nayyar, A M Lawrence, E Paloyan. 1993. Hyperparathyroidism induced by hypothyroidism.. https://doi.org/10.1288/00005537-199303000-00005

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