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PubMed · 8447209

Doxapram improves pulmonary function after upper abdominal surgery.

L Björk·M Arborelius·H Renck·B Rosberg
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Abstract

The effects of doxapram on postoperative pulmonary function were studied in 40 ASA I and II patients randomly allocated to receive either doxapram 1.8 mg.kg-1.h-1 or placebo for 2 h immediately after elective cholecystectomy. The two groups displayed similar reductions of carbon dioxide production at 2 h and 6 h postoperatively, whereas oxygen consumption remained at preoperative levels for 24 h. Minute ventilation was similarly reduced in the two groups at 2 h and 6 h postoperatively, with corresponding increases in PaCO2. PaO2 was similarly and significantly decreased in both groups postoperatively, whereas P(A-a)O2 remained unchanged at 2 h and 6 h in doxapram-treated patients. FRC was reduced postoperatively in both groups, significantly more so in the control group at 6 h. Various indices of intrapulmonary gas distribution, including the functional (nitrogen) dead space, underwent similar changes in the two groups. By contrast, the physiological dead space was reduced in doxapram-treated patients at 2 h, 6 h and 24 h postoperatively, whereas no significant changes were seen in the control group. The ventilatory equivalent for CO2 was significantly lower in the doxapram-treated group, implying higher ventilatory efficiency. Our findings indicate that infusion of doxapram postoperatively attenuates the impairment of pulmonary function postoperatively, chiefly via effects on V'A/Q' ratios. No side effects of doxapram were observed.

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AbdomenBlood PressureCarbon DioxideCholecystectomyDoxapramFemaleFunctional Residual CapacityHumansInfusions, IntravenousLungLung ComplianceMaleMiddle AgedNauseaOxygen ConsumptionPlacebosPulmonary AlveoliRespirationRespiratory Dead SpaceTidal VolumeVomitingClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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L Björk, M Arborelius, H Renck, B Rosberg. 1993. Doxapram improves pulmonary function after upper abdominal surgery.. https://doi.org/10.1111/j.1399-6576.1993.tb03697.x

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