MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis.

M Hasegawa; H Kinoshita; M Amano; T Hasegawa; T Kameyama; T Nabeshima

doi:10.1016/0304-3940(93)90106-u

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MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis.

M Hasegawa·H Kinoshita·M Amano·T Hasegawa·T Kameyama·T Nabeshima

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Abstract

Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5, 10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10(-2) M N-methyl-D-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.

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Acetylcholine Animals Dialysis Dizocilpine Maleate Extracellular Space Kinetics Male N-Methylaspartate Neurons Parietal Lobe Rats Rats, Wistar Reference Values Time Factors Journal Article

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M Hasegawa, H Kinoshita, M Amano, T Hasegawa, T Kameyama, T Nabeshima. 1993-02-05. MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis.. https://doi.org/10.1016/0304-3940(93)90106-u

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