PubMed · 8482772
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B P Isenberg. 1993. CAD-CAM comments.. https://doi.org/10.14219/jada.archive.1993.0115
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The bending art system (BAS) enables computerized production of individual arch wires for the multiband technique. Treatment planning using the continuous arch technique as part of the bending art system has been described. Planning of the arch wires follows an initial camera picture taken in the patient's mouth, and is divided into the following steps: ideal arch, target arch and course of treatment. The ideal arch establishes the individual shape of the arch wires in the horizontal plane. Based on the input of various small adjustments, the ideal arch is transformed into the target arch which represents the final arch of the treatment. Finally, the sequence of the various arches is established. The geometry of the intermediate arches is calculated on the assumption that each tooth is moved the shortest possible distance during transformation from the initial arch to the target arch. This procedure, called the direct method, is compared with the newly developed indirect method. With the indirect method, the camera picture is taken of the initial cast and the target arch is produced in accordance with a setup model in ideal occlusion. In contrast to the straight-wire technique, treatment with the BAS is not finalized with a straight arch wire since the occlusion of the individual patient rarely complies with the straight-wire norm.
This paper describes a novel methodology, PRO_SELECT, which combines elements of structure-based drug design and combinatorial chemistry to create a new paradigm for accelerated lead discovery. Starting with a synthetically accessible template positioned in the active site of the target of interest, PRO_SELECT employs database searching to generate lists of potential substituents for each substituent position on the template. These substituents are selected on the basis of their being able to couple to the template using known synthetic routes and their possession of the correct functionality to interact with specified residues in the active site. The lists of potential substituents are then screened computationally against the active site using rapid algorithms. An empirical scoring function, correlated to binding free energy, is used to rank the substituents at each position. The highest scoring substituents at each position can then be examined using a variety of techniques and a final selection is made. Combinatorial enumeration of the final lists generates a library of synthetically accessible molecules, which may then be prioritized for synthesis and assay. The results obtained using PRO_SELECT to design thrombin inhibitors are briefly discussed.
Cycle safety helmets are designed to prevent head injury. Although most commercially available helmets conform to one of several national and international standards, individual designs differ widely, particularly in relation to face coverage. A method was developed to assess the potential for the differing designs to protect the face from injury. A nonimpact test was assessed, using digitized image-processing software (Digithurst Ltd.) to measure the shadow cast by a helmet rim under a collimated plane light source onto the face of a mannequin headform. Twelve helmet designs available internationally were tested and ranked with respect to the direct protection conferred (area of the face directly covered by the helmet) and indirect protection (area of the face shaded). The three highest-ranking helmets for direct protection (Rosebank Stackhat, Asphalt Warrior, and Lazer Voyager) also ranked the highest for indirect protection. These helmets were more inferiorly extended and were of a more bulky construction. It was concluded that the dimensions of cycle helmets in relation to face coverage are crucial in influencing the extent to which facial protection is conferred. International test standards need urgent revision to ensure that face coverage is optimized. Lower-face protection could be achieved through incorporation of a lower-face bar to cycle helmets.