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PubMed · 8498832

Systemic histiocytosis presenting as multiple sclerosis.

M E Smith·D A Katz·J O Harris·J A Frank·C V Kufta·D E McFarlin
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Abstract

A patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non-Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.

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BiopsyBone and BonesBrainBrain DiseasesDiagnosis, DifferentialFollow-Up StudiesGlial Fibrillary Acidic ProteinHistiocytesHistiocytosisHumansImmunohistochemistryMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisRadiographyRadionuclide ImagingCase ReportsJournal Article

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M E Smith, D A Katz, J O Harris, J A Frank, C V Kufta, D E McFarlin. 1993. Systemic histiocytosis presenting as multiple sclerosis.. https://doi.org/10.1002/ana.410330521

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