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Lessons from lethal albino mice.

G Kelsey·G Schütz
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Abstract

Results from the analysis of mice homozygous for lethal albino deletions suggested the existence of a locus involved in the regulation of gene expression in the liver. The surprising finding that the locus encodes an enzyme active in tyrosine metabolism forces us to re-evaluate the lethal albino phenotype and advises caution in the interpretation of seemingly simple phenotypes.

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AlbinismAnimalsAnimals, NewbornGene DeletionGene Expression RegulationGenes, LethalHumansHydrolasesLiverMiceMice, Mutant StrainsMice, TransgenicModels, BiologicalOrgan SpecificityPhenotypeTranscription FactorsTranscription, GeneticTyrosineComparative StudyJournal ArticleReview

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G Kelsey, G Schütz. 1993. Lessons from lethal albino mice.. https://doi.org/10.1016/0959-437x(93)90032-k

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