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Foamy virus vectors.

D W Russell·A D Miller
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Abstract

Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.

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3T3 CellsAnimalsBloodCHO CellsCell DivisionCell LineCell Line, TransformedChlorocebus aethiopsCricetinaeGenetic VectorsGenome, ViralHumansLeukemia Virus, MurineMiceRatsSpumavirusTransduction, GeneticVero CellsVirus IntegrationJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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D W Russell, A D Miller. 1996. Foamy virus vectors.. https://doi.org/10.1128/jvi.70.1.217-222.1996

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