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A role for CD81 in early T cell development.

R Boismenu·M Rhein·W H Fischer·W L Havran
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Abstract

Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of alpha beta but not gamma delta T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4-CD8- thymocytes differentiated into CD4+CD8+ T cells. Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development.

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Amino Acid SequenceAnimalsAntibodies, MonoclonalAntigens, CDBase SequenceCD4 AntigensCD8 AntigensCHO CellsCell DifferentiationCricetinaeMembrane ProteinsMiceMolecular Sequence DataOrgan Culture TechniquesReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaStromal CellsT-Lymphocyte SubsetsTetraspanin 28Thymus GlandTransfectionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R Boismenu, M Rhein, W H Fischer, W L Havran. 1996-01-12. A role for CD81 in early T cell development.. https://doi.org/10.1126/science.271.5246.198

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