Quantification of renal function with a count-based gamma camera method using technetium-99m-MAG3 in children.

K Itoh; K Nonomura; T Yamashita; K Kanegae; M Murakumo; T Koyanagi; M Furudate

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PubMed · 8544005

Quantification of renal function with a count-based gamma camera method using technetium-99m-MAG3 in children.

K Itoh·K Nonomura·T Yamashita·K Kanegae·M Murakumo·T Koyanagi·M Furudate

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Abstract

UNLABELLED: To evaluate renal function quantitatively without blood sampling in children, renal uptake by gamma camera renography using 99mTc-MAG3 was compared with plasma clearance by a single blood sample method as the reference. METHODS: Twenty children (15 boys, 5 girls; aged 2-14 yr) with nephrourological diseases were examined prospectively in this study. The patient received an intravenous administration of 5 MBq/kg 99mTc-MAG3 which was prepared using a commercially available kit. Gamma camera renography was performed and the renal uptake per injected dose (%RU) of the 1-min period of postinjection was calculated from a background-corrected renogram curve by computer. The plasma clearance (Clmag) of 99mTc-MAG3 was calculated by the single blood sample method at 35 min postinjection. RESULTS: The %RU of the 1-min period in the 1-3 min postinjection correlated well with Clmag. The best correlation was observed 1-2 min postinjection. The regression equation between total %RU (X) and Clmag (Y) (ml/min/1.73 m2) was Y = -98.509 + 20.373X (r = 0.910, s = 84.19) with standardization by BSA. The best fit regression equation between individual %RU (X) and Clmag (Y) (ml/min/1.73m2) was Y = -43.799 + 19.917X (p = 0.932, s = 43.27). CONCLUSION: The renal uptake method based on separate counts by gamma camera renography using 99mTc-MAG3 does not require a blood sample for quantification of renal function and may be potentially more practical in children.

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Adolescent Algorithms Child Child, Preschool Evaluation Studies as Topic Female Gamma Cameras Humans Infant Male Prospective Studies Radioisotope Renography Renal Plasma Flow, Effective Technetium Tc 99m Mertiatide Urologic Diseases Comparative Study Journal Article

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K Itoh, K Nonomura, T Yamashita, K Kanegae, M Murakumo, T Koyanagi, M Furudate. 1996. Quantification of renal function with a count-based gamma camera method using technetium-99m-MAG3 in children.. https://pubmed.ncbi.nlm.nih.gov/8544005/

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