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PubMed · 8552902

Exact power computation for dose-response studies.

M L Tang·K F Hirji·S E Vollset
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Abstract

The toxicity of an agent or the therapeutic effect of a drug may be assessed by a dose-response study. We present a method for computing the exact power of exact and large sample statistical tests employed for binary response data from such a study. This method, based on recursive polynomial multiplications, enables fast computation of exact power for studies with up to a moderately large sample size. We demonstrate the efficiency of our method using three examples. The method is suitable for the design and power analysis of dose-response studies in which the usual asymptotic approximations are suspect.

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AdenomaAlgorithmsAnimalsDose-Response Relationship, DrugEmbryonic and Fetal DevelopmentFemaleGABA AgentsHumansLinear ModelsLogistic ModelsMaleMethanolMicePituitary NeoplasmsPregnancyRatsRats, WistarReproducibility of ResultsSample SizeSoftwareTestisToxicologyUnithiolValproic AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M L Tang, K F Hirji, S E Vollset. 1995-10-30. Exact power computation for dose-response studies.. https://doi.org/10.1002/sim.4780142009

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