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Immunoinfertility: a case study with implications for immunocontraception.

G N Clarke·D Y Liu·H W Baker
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Abstract

A detailed case history was compiled on a couple who have had primary infertility for more than 20 years. The history and further laboratory investigations indicated that the infertility was caused by high-titre sperm antibodies in the female. The antibodies blocked sperm-zona binding and reacted with a prominent band at 65 kD in Western blots. Preliminary studies indicate that a subset of the patient's antibodies are specific for a unique protein sequence expressed by a cDNA testis library. This antigen may have potential for immunocontraceptive vaccine development.

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AntibodiesBlotting, WesternCervix MucusContraceptionElectrophoresis, Polyacrylamide GelFemaleFertilization in VitroHumansImmunoglobulin GInfertility, MaleMaleOocytesSperm-Ovum InteractionsSpermatozoaZona PellucidaCase ReportsJournal Article

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G N Clarke, D Y Liu, H W Baker. Immunoinfertility: a case study with implications for immunocontraception.. https://doi.org/10.3109/01485019508987849

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