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PubMed · 8564441

Renal chloride-bicarbonate exchangers.

M J Godinich·M L Jennings
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Abstract

This review discusses the molecular identities and functional properties of sodium-independent Cl(-)-HCO3- exchangers in the kidney. The main sites of renal Cl(-)-HCO3- exchange are in the intercalated cells of the collecting duct. The function of Cl(-)-HCO3- exchange is to provide a pathway for base efflux to balance the ATP-driven H+ efflux in cells that carry out transcellular net transport of H+. In the alpha-intercalated cell, which secretes H+ into the lumen, there is now excellent evidence that the basolateral Cl(-)-HCO3- exchanger is an N-terminal truncated form of the erythrocyte anion exchanger 1 (band 3) protein. In the beta-intercalated cell, which secretes HCO3-, it is well established that there is a Cl(-)-HCO3- exchanger in the apical membrane. Functional, immunocytochemical, and biochemical evidence indicate that the apical Cl(-)-HCO3- exchanger is not a product of the anion exchanger 1 gene. The identity of this protein remains uncertain.

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M J Godinich, M L Jennings. 1995. Renal chloride-bicarbonate exchangers.. https://doi.org/10.1097/00041552-199509000-00004

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