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PubMed · 8570518

Computer simulation of tablet motion in coating drum.

K Yamane·T Sato·T Tanaka·Y Tsuji
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Abstract

PURPOSE: The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation. METHODS: DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation. RESULTS: The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers. CONCLUSIONS: It is found that DEM is a useful method of predicting tablet motion in a coating drum.

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Computer SimulationDrug CompoundingMotionPhysical PhenomenaPhysicsRotationTabletsTime FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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K Yamane, T Sato, T Tanaka, Y Tsuji. 1995. Computer simulation of tablet motion in coating drum.. https://doi.org/10.1023/a%3A1016201102355

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