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PubMed · 8586891

Decrease of interferon-induced 2',5'-oligoadenylate synthetase activity in cirrhotic rat liver.

I Miyajima·M Sata·Y Uchimura·H Suzuki·K Tanikawa
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Abstract

We evaluated the effect of hepatic fibrosis on the induction of hepatic 2',5'-oligoadenylate synthetase (2-5AS) by interferon (IFN) in a rat model of liver cirrhosis, induced with thioacetamide. Although there was no difference in serum 2-5AS activity between the control and cirrhotic rats given murine IFN, 2-5AS activity in the liver homogenates of cirrhotic rats was significantly lower than in the controls (105 +/- 18.5 vs. 171 +/- 10.2 pmol/micrograms, p < 0.01). These results suggested that hepatic fibrosis attenuated the effect of IFN and one of the reasons for this may be the decreased induction of hepatic 2-5AS activity after IFN administration in the presence of a cirrhotic liver.

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2',5'-Oligoadenylate SynthetaseAnimalsInterferonsLiver Cirrhosis, ExperimentalMaleRatsRats, WistarThioacetamideJournal ArticleResearch Support, Non-U.S. Gov't

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I Miyajima, M Sata, Y Uchimura, H Suzuki, K Tanikawa. 1995. Decrease of interferon-induced 2',5'-oligoadenylate synthetase activity in cirrhotic rat liver.. https://doi.org/10.11150/kansenshogakuzasshi1970.69.1383

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