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MtDNA-encoded histocompatibility antigens.

V M Dabhi·K F Lindahl
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Abstract

Mitochondrially encoded H antigens are by-products of a system that has evolved in vertebrates to present peptides from intracellular pathogens on the cell surface for detection by CTLs, which can lyse the infected cell. CTL lines and clones with defined specificity against mitochondrial H antigens, which can be maintained in culture for long periods, offer a unique tool in mitochondrial genetics. Expression of polymorphic mitochondrial H antigens depends on both the presence and the activity of the corresponding mitochondrial genome, and CTLs can provide strong selection against cells displaying their cognate antigen.

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AnimalsCell LineCells, CulturedChromium RadioisotopesClone CellsCulture TechniquesDNA, MitochondrialGene ExpressionGenetic VariationHLA AntigensHistocompatibility AntigensHumansInterleukin-2Killer Cells, NaturalLymphocyte ActivationLymphocyte Culture Test, MixedMajor Histocompatibility ComplexMiceMice, Inbred StrainsMitochondriaPolymorphism, GeneticRatsRats, Inbred LewRats, Inbred StrainsT-LymphocytesT-Lymphocytes, CytotoxicTissue DonorsTransplantation ImmunologyVertebratesJournal Article

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V M Dabhi, K F Lindahl. 1995. MtDNA-encoded histocompatibility antigens.. https://doi.org/10.1016/0076-6879(95)60159-7

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