The HSSP database of protein structure-sequence alignments.

R Schneider; C Sander

doi:10.1093/nar/24.1.201

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The HSSP database of protein structure-sequence alignments.

R Schneider·C Sander

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Abstract

HSSP is a derived database merging structural three dimensional (3-D) and sequence one dimensional(1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in Swissprot using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 27% of all Swissprot-stored sequences.

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Amino Acid Sequence Computer Communication Networks Databases, Factual Molecular Sequence Data Protein Structure, Secondary Protein Structure, Tertiary Proteins Sequence Alignment Journal Article

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R Schneider, C Sander. 1996-01-01. The HSSP database of protein structure-sequence alignments.. https://doi.org/10.1093/nar%2F24.1.201

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