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PubMed · 8600834

A biosensor concept based on imaging ellipsometry for visualization of biomolecular interactions.

G Jin·P Tengvall·I Lundström·H Arwin
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Abstract

A new type of optical biosensor system is proposed and its application to detection of antigen-antibody complexes on a silicon substrate is demonstrated. The biosensor system is utilizing specificities of biomolecular interactions in combination with protein patterned surfaces. Visualization of the thickness distributions of thin layers (protein patterns) on a surface is achieved by using imaging ellipsometry. This technique uses a CCD camera whereby an ellipsometric analysis of a large surface can be made. The biosensor system has the advantages of high spatial resolution, fast data acquisition, and simplicity in use.

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AdsorptionAntigen-Antibody ComplexBiosensing TechniquesFibrinogenImmunoglobulin GLightSerum AlbuminSurface PropertiesVideo RecordingJournal ArticleResearch Support, Non-U.S. Gov't

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G Jin, P Tengvall, I Lundström, H Arwin. 1995-11-20. A biosensor concept based on imaging ellipsometry for visualization of biomolecular interactions.. https://doi.org/10.1006/abio.1995.9959

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