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Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations.

B P Kropp·M K Rippy·S F Badylak·M C Adams·M A Keating·R C Rink·K B Thor
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Abstract

PURPOSE: To evaluate small intestinal submucosa (SIS) as a possible bladder augmentation material. MATERIALS AND METHODS: Nineteen male dogs underwent 35 to 45% partial cystectomy with immediate augmentation with SIS grafts. All dogs were evaluated pre- and postoperatively with blood chemistries, urine cultures, intravenous urograms, cystograms and cystometrograms. Postoperatively (1 to 15 months), bladders were examined with routine histology and image analysis. RESULTS: All dogs survived their intended survival period without morbidity. All results were normal. Histologically, all 3 layers (mucosa, smooth muscle, serosa) of the normal bladder showed evidence of regeneration. CONCLUSIONS: Small intestinal submucosa acts as a scaffold for bladder augmentation through regeneration and could be a potential option for bladder reconstruction.

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AnimalsCystectomyDogsImage Processing, Computer-AssistedIntestinal MucosaJejunumMaleMuscle, SmoothRegenerationTime FactorsUrinary BladderUrodynamicsJournal Article

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B P Kropp, M K Rippy, S F Badylak, M C Adams, M A Keating, R C Rink, K B Thor. 1996. Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations.. https://doi.org/10.1016/s0022-5347(01)66117-2

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