PubMed · 8659740
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R E Johnstone. 1996. Flexible coordination allows more cases.. https://doi.org/10.1097/00000539-199607000-00040
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1. We have investigated the permeability-increasing effect of arachidonic acid on pial venular capillaries in vivo using the single microvessel occlusion technique. 2. Permeability to Lucifer Yellow dye (476 Da) increased dose dependently when arachidonic acid was applied focally to the abluminal surface of the vessels. This was completely reversible at all but the highest dose. The permeability increase was 1.65 x 10(-6) +/- 0.247 x 10(-6) cm s-1 (mean +/- S.E.M.) at 0.25 mM, 3.53 x 10(-6) +/- 0.872 x 10(-6) cm s-1 at 0.5 mM, 12.61 x 10(-6) +/- 3.44 x 10(-6) cm s-1 at 1 mM and 18.46 x 10(-6) +/- 5.90 x 10(-6) cm s-1 at 2 mM arachidonic acid. There was a similar reversible dose-dependent permeability increase to eicosapentaenoic acid. 3. These permeability increases could be prevented by co-application of a mixture of the antioxidants superoxide dismutase and catalase (30 and 100 U ml-1), or by the iron chelator desferrioxamine (100 microM). 4. The permeability increases were also prevented by the cyclooxygenase and 5-lipoxygenase blockers indomethacin (100 microM) and nordihydroguariaretic acid (100 microM), respectively, when applied together, but not singly. 5. It was concluded that the permeability response to arachidonic acid depends on the formation of free radicals and subsequent lipid peroxidation.
Methodology for assessment of depth of anaesthesia based on analysis of the electroencephalogram (eeg) is controversial. Techniques range from display of single measures, for example median value of the frequency spectrum, to dedicated pattern recognition systems based on measures of several eeg features. We have compared the performance of four techniques using tape-recorded data from 23 patients anaesthetised with either halothane or isoflurane using standardised regimens. The techniques were: median frequency, spectral edge frequency, the cerebral function analysing monitor (CFAM-1) and a depth of anaesthesia monitor based on eeg pattern recognition (ADAM). Dose-response curves are presented for stepwise increases in stable end-tidal concentrations of each agent. Results indicated considerable inter-patient variability and showed the limitations of single eeg measures, particularly with deeper anaesthesia producing burst suppression patterns in the eeg. Pattern recognition techniques reduced these difficulties and appeared to be promising over a wide range of anaesthetic levels.