PubMed · 8696323
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I Thesleff. 1996. Two genes for missing teeth.. https://doi.org/10.1038/ng0896-379
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During the last eight years, Canterbury Archaeological Trust has excavated over 1,600 articulated human skeletons from sites under threat of redevelopment in Kent. The recovered material, ranging in date from prehistoric to Victorian, provides a unique corpus for the study of disease and abnormalities in earlier societies.
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Hypodontia has been observed as one of the most common human dental developmental anomalies. It may be defined as agenesis of one or more teeth. The prevalence in the permanent lower central and lateral incisor region is low, ranging from 0.23 percent to 0.08 percent, respectively. This is compared with an overall incidence of hypodontia of 3.49 percent. However, significant racial variation occurs. Treatment options generally available are: no treatment, closure of spaces orthodontically, or prosthetic replacement. Aetiology, associated anomalies, and factors involved in treatment choice are discussed. A report of four cases of hypodontia of the permanent lower anterior teeth and their orthodontic management is presented.