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PubMed · 8701412

Characterization of a cDNA encoding murine coagulation factor VII.

E Idusogie·E Rosen·J P Geng·P Carmeliet·D Collen·F J Castellino
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Abstract

The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a lambda Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3' poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII.

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Amino Acid SequenceAnimalsBase SequenceCattleCloning, MolecularCoronary DiseaseDNA, ComplementaryDogsFactor VIIGenetic CodeHumansMacaca mulattaMiceMolecular Sequence DataPoint MutationRabbitsSequence Homology, Amino AcidSpecies SpecificityJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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E Idusogie, E Rosen, J P Geng, P Carmeliet, D Collen, F J Castellino. 1996. Characterization of a cDNA encoding murine coagulation factor VII.. https://pubmed.ncbi.nlm.nih.gov/8701412/

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