Serotonergic modulation of cat bladder function before and after spinal transection.

M J Espey; J W Downie

doi:10.1016/0014-2999(95)00614-1

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Serotonergic modulation of cat bladder function before and after spinal transection.

M J Espey·J W Downie

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Abstract

Micturition was evoked in conscious cats by infusing saline into the bladder at a physiological rate. Drugs were administered intrathecally. Micturition volume threshold was increased by 5-hydroxytryptamine (5-HT, serotonin) and decreased by zatosetron, a 5-HT3 receptor antagonist, in spinally intact cats. Thus 5-HT3 receptors inhibit micturition. After complete spinal transection, serotonin reduced volume threshold in 3 of 4 cats, indicating an alteration in serotonergic control. However, 2-methyl-5-HT, a 5-HT3 receptor agonist, increased volume threshold. Thus 5-HT3 receptor-mediated inhibition of bladder function remains after spinal transection. We conclude that some, but not all, serotonergic modulation of bladder function is altered after spinal transection.

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M J Espey, J W Downie. 1995-12-12. Serotonergic modulation of cat bladder function before and after spinal transection.. https://doi.org/10.1016/0014-2999(95)00614-1

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