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Mechanoreceptive afferents exhibit functionally-specific activity dependent changes in conduction velocity.

S S Waikar·J G Thalhammer·S A Raymond·J H Huang·D S Chang·G R Strichartz
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Abstract

Impulse activity in axons generates aftereffects on membrane excitability that can alter the conduction velocity of subsequently conducted impulses. We used a computerized stimulus pattern (a 1 Hz stimulus period followed by a period of repeated short bursts at 200 Hz) to assess in vivo activity-dependent changes in conduction latency of functionally identified rat cutaneous afferents conducting in the A beta range. Several different parameters of activity dependence were measured: burst supernormality, the average increase in conduction latency following conditioning with a single preceding impulse during high frequency burst stimulation; burst subnormality, the average latency increase during each burst; depression, a long-term increase in latency caused by the high frequency stimulation. The data show that different mechanosensitive A beta afferents with overlapping resting conduction velocities exhibit activity-dependent changes in conduction latency that are characteristic of their particular functions.

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AnimalsAxonsElectric StimulationMechanoreceptorsNeural ConductionNeurons, AfferentRatsSciatic NerveSkinJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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S S Waikar, J G Thalhammer, S A Raymond, J H Huang, D S Chang, G R Strichartz. 1996-05-20. Mechanoreceptive afferents exhibit functionally-specific activity dependent changes in conduction velocity.. https://doi.org/10.1016/0006-8993(96)00165-5

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