Pax proteins and eye development.

R Macdonald; S W Wilson

doi:10.1016/s0959-4388(96)80008-0

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PubMed · 8794051

Pax proteins and eye development.

R Macdonald·S W Wilson

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Abstract

Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure.

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Animals Eye Genes Humans Models, Neurological Mutation Phenotype Transcription Factors Journal Article Research Support, Non-U.S. Gov't Review

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R Macdonald, S W Wilson. 1996. Pax proteins and eye development.. https://doi.org/10.1016/s0959-4388(96)80008-0

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