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Evidence for antigenic distinctness of the Epstein--Barr virus-determined nuclear antigen and the Herpesvirus papio-determined nuclear antigen.

S Ohno·J Luka·G Klein
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Abstract

Previous serological evidence indicated that Epstein--Barr virus-determined nuclear antigen (EBNA) has cross reactive components with the herpesvirus papio-determined nuclear antigen (HUPNA) and, in addition, it has distinct components of its own, not present in HUPNA. In the present study, this hypothesis was studied by absorption experiments. Absorption of anti-EBNA positive human sera with EBNA abolished both anti-EBNA and anti-HUPNA reactivity. Absorption with HUPNA removed all anti-HUPNA reactivity but did not reduce anti-EBNA to any detectable degree, thus confirming the hypothesis.

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AnimalsAntibodies, ViralAntigens, ViralCell NucleusCross ReactionsEpitopesHaplorhiniHerpesviridaeHerpesvirus 4, HumanHumansImmunosorbent TechniquesPapioSpecies SpecificityJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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S Ohno, J Luka, G Klein. 1979. Evidence for antigenic distinctness of the Epstein--Barr virus-determined nuclear antigen and the Herpesvirus papio-determined nuclear antigen.. https://doi.org/10.1016/s0304-3835(79)80089-0

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