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Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.

Q Chen·A H Andersen·Z Zhang·A Ovadia·D M Gash·M J Avison
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Abstract

A multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrainBrain MappingCarbidopaFemaleLevodopaMacaca mulattaMagnetic Resonance ImagingParkinson Disease, SecondaryJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Q Chen, A H Andersen, Z Zhang, A Ovadia, D M Gash, M J Avison. 1996. Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.. https://doi.org/10.1016/0730-725x(95)02100-8

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