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PubMed · 8893692

Is leukocytospermia clinically relevant?

E H Yanushpolsky·J A Politch·J A Hill·D J Anderson
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Abstract

OBJECTIVE: To evaluate the relationship between seminal leukocytes and abnormal semen parameters in a large population of infertility patients. DESIGN: Prospective clinical study. SETTING: Center for Reproductive Medicine at Brigham and Women's Hospital, Boston, Massachusetts. PATIENT(S): One thousand seven hundred ten male partners in infertile couples attending the Center for Reproductive Medicine. MAIN OUTCOME MEASURE(S): Seminal leukocyte concentrations, sperm count, motility and morphology, and the prevalence of samples with < 10 x 10(6) motile sperm per ejaculate (a parameter defined by IVF as the most clinically significant predictor of male infertility). RESULT(S): There was a strong relationship between increasing leukocyte concentrations in semen and abnormal semen parameters. Statistically significant differences in sperm concentrations and morphology were observed at leukocytospermia thresholds of 5 x 10(5) and 2 x 10(6) granulocytes/mL, respectively. The percentage of suboptimal semen specimens as defined by IVF criteria (< 10(7) total motile sperm per ejaculate) significantly increased with increasing seminal granulocyte concentrations. A twofold increased prevalence in such suboptimal semen specimens was observed at the leukocytospermia threshold of 2 x 10(6) granulocytes/mL. CONCLUSION(S): There is a relationship between increasing seminal granulocyte concentrations and poor semen parameters. At seminal granulocyte concentrations > 2 x 10(6)/mL, semen parameter abnormalities were observed that were both statistically and clinically significant.

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Fertilization in VitroGranulocytesHumansInfertility, MaleLeukocyte CountLeukocytesMaleProspective StudiesSemenSperm CountSperm MotilitySpermatozoaJournal Article

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BibTeXRIS

E H Yanushpolsky, J A Politch, J A Hill, D J Anderson. 1996. Is leukocytospermia clinically relevant?. https://pubmed.ncbi.nlm.nih.gov/8893692/

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