Interaction between corticosteroids and beta-agonists in asthma.

P J Wilding; A E Tattersfield

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PubMed · 8901320

Interaction between corticosteroids and beta-agonists in asthma.

P J Wilding·A E Tattersfield

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Abstract

It is often assumed that there is synergy between corticosteroids and beta-agonists, the two drugs most commonly used to treat asthma. A review of clinical studies of the effect of corticosteroids on the response to a beta-agonist finds no evidence to support this assumption except in subjects taking high doses of beta-agonists and with diminished responsiveness to a beta-agonist. There is some evidence that regular beta-agonist therapy may cause a temporary reduction in the efficacy of corticosteroids in asthma, an effect that is seen when the response to the beta-agonist has worn off. Further studies of this effect are required in view of the very widespread concomitant use of the two drugs.

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Adrenal Cortex Hormones Adrenergic beta-Agonists Asthma Clinical Trials as Topic Drug Interactions Humans Treatment Outcome Journal Article Review

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P J Wilding, A E Tattersfield. 1996. Interaction between corticosteroids and beta-agonists in asthma.. https://pubmed.ncbi.nlm.nih.gov/8901320/

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